Sep 2, 2019
Join the EMGuideWire
Team,from Carolinas Emergency Medicine
Residency Program in Charlotte, NC, as they
explore the critical core concepts on the important topic of
Sepsis. In this first episode, the team will discuss the
definitions of Sepsis.
- Sepsis is a dysregulated systemic inflammatory response to
infection causing intravascular inflammation, tissue ischemia,
cytopathic injury, and dysregulated apoptosis.
- SIRS terminology is now outdated. Current terminology is
“Sepsis” (SIRS, suspected source, end organ damage) and “Septic
- Septic shock: SBP <90 or MAP <65 despite fluids; or if
lactate is >2 after fluids.
- qSOFA = RR > 22, AMS, SBP < 100; 2-3 points = poor
- Epidemiology: 164,000 cases annually. Bacterial etiology most
common. Mortality for sepsis and septic shock is 10 and 40%
Summarized by Travis Barlock, MD PGY-1
- Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of
sepsis in the United States from 1979 through 2000. New England
Journal of Medicine 2003; 348:1546.
- Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of Clinical
Criteria for Sepsis: For the Third International Consensus
Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA